sri.Arun Shankar ji,--thanks for your input.
I mean "futile" in the sense-- insisting that my grandmother's(Paatti's) "Eeya chombu rasam" is very "tasty" and all that.Precisely i meant the chelation of Ferrum and prevention of the formation of Heme (the Prosthetic group) of Hemo-globin-and the enzyme ferrochelatase--resulting in Anemia.Another protein affected is Ferritin in the blood.I did not want to go deeply into the mechanisms and all that.It is "chronic" toxicity-so one does see the effects immediately,unless the blood and tissue levels cross a "Threshold" vaue and results in "acute" emergency.
A lot of information on "Lead Poisoning" is available in the literature and in developed countries "Lead Abatement' from old buildings and inspection for lead contamination in new buildings is a Billion Dollar business.Chinese and Indian toys reported to conain a lot of lead have been banned in many Euro-American countries.Recent evidences are accumulating regarding "Lead" affecting the developement of small childrens'brain activities.
I want you to be clear here Dr. Somayaji
I am not looking for the toxicity information of lead I myself as I have mentioned in this thread earlier written a detail review based on state of the art literature and my own research on the of toxicity and mode of action of all important heavy metals Please do have a look at the review here
http://www.agriculture.frih.net/c21.pdf
I will paste the part on lead here as follows
Mode of Toxic Action. Possible mechanisms for lead toxicity include
competition with and substitution for calcium, disruption of calcium homeostasis, stimulation of release of calcium from mitochondria, and opening of mitochondrial transition pore. In addition, direct damage to mitochondria and mitochondrial membranes by generation of ROS is also seen. Disruption of tissue oxidant/antioxidant balance, alteration of lipid metabolism, and substitution for zinc in various zinc-mediated processes are some of the metabolic repercussions of lead toxicity [Ahamed et al., 2007]. Lead toxicity development due to calcium interaction has gained considerable amount of attention by researchers. Calcium blocks the uptake of lead through the intestine because lead is a strong blocker of
calcium channels. Lead and calcium compete for the same binding sites on a large family of ion-binding proteins composed of calmodulin and related proteins. Calmodulin serves as a sensor for the concentration of calcium within cells. Lead acts by displacing calcium ions bound to calmodulin. Lead impairs normal calcium homeostasis and uptake by calcium membrane channels and substitutes for calcium in calcium
sodium ATP pumps. Impact of lead on brain activity is explained by the fact that lead also blocks access of calcium into nerve terminals, thereby blocking calcium movement into the mitochondria of brain cells, resulting in a decrease in energy production to perform brain functions. Lead also blocks heme synthesis, thereby increasing levels of the precursor daminolevulinic acid (ALA). ALA suppresses GABAmediated
neurotransmission by inhibiting its release and also possibly by competing with GABA at receptors. Lead also can produce anemia, both by interfering with heme synthesis and by decreasing iron absorption from the gut. Lead’s ability to substitute for zinc, mentioned previously, affords another avenue by which lead can act as a neurodevelopmental toxicant. By displacing zinc, lead can alter the regulation of genetic transcription through sequence-specific DNA-binding zinc finger protein or zinc-binding sites in receptor channels (Arun Shanker 2008)
Ref
Arun K Shanker (2008) Mode of action and toxicity of trace elements In: Trace Elements as Contaminants and Nutrients: Consequences in Ecosystems and Human Health Edited by: M. N. V. Prasad. Pp 523-550 John Wiley & Sons, Inc
What I want to know here is 1.What is the composition of Eya Chombu as determined in PPM quantity of lead (Pb) by Atomic Absorption Spectro or ICPMS?
2. what is the variation in this qty in various eya chombu found in shops in TN
3. What is the amount of lead in PPM that in transferred to the Rasam and in turn what is the qty that is taken up by the body
4. Is that qty enough to trigger its toxic mode of action
5. What are the hazards of storage of rasam and is it advisable to store if up to what length of time
There is one article of relevance here I have uploaded in my earlier post
http://www.tamilbrahmins.com/general-discussions/2215-eeya-chombu-rasam-unique-tbs-4.html#post23063
Thanks
Arun